Calcitonin R Antibody (462815) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 462815
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

Calcitonin R Antibody (462815) [Alexa Fluor® 350] Summary

• Immunogen: HEK293 human embryonic kidney cell line transfected with human Calcitonin R
  Ala25-Ala474
  Accession # NP_001733
• Specificity: Detects human Calcitonin R in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Calcitonin R Antibody (462815) [Alexa Fluor® 350]

• Calcitonin R
• calcitonin receptor
• CalcitoninR
• CALCR
• CRT
• CTR
• CT-R
• CTR1

Background

Calcitonin receptor (CALCR) is a glycosylated 70 kDa seven-transmembrane G protein-coupled receptor that mediates the hypocalcemic effects of the peptide hormone, calcitonin. CALCR activation inhibits osteoclast-mediated bone resorption and enhances renal calcium excretion. CALCR polymorphisms and mutations have been associated with several bone disorders. Alternative splicing results in the deletion of 16 aa in the first cytoplasmic loop or 23 aa in the first extracellular region. Human CALCR shares 70%‑72% aa sequence identity with mouse and rat CACLR.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.