Calcitonin R Antibody (31/01-1H10-4-1-14) - BSA Free

Product Discontinued

Calcitonin R Antibody (31/01-1H10-4-1-14) - BSA Free Summary

• Immunogen: Synthetic peptide, DIPIYICHQELRNEPANN, derived from the cytoplasmic domain of human calcitonin receptor.
• Localization: Integral membrane protein
• Specificity: This recognises an epitope within the cytoplasmic domain that is common to both C1a and C1b human isoforms.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: CALCR
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:1000-1:5000
  • Flow Cytometry 1:10-1:1000
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:500
  • Western Blot 1:100-1:2000
• Application Notes: This product does not require protein digestion pre-treatment of paraffin embedded sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin embedded sections. We recommend the use of 4% paraformaldehyde fixation, rather than formalin fixation.

Reactivity Notes

Reacts with Human. Cross reacts with Rabbit.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A purified

Alternate Names for Calcitonin R Antibody (31/01-1H10-4-1-14) - BSA Free

• Calcitonin R
• calcitonin receptor
• CalcitoninR
• CALCR
• CRT
• CTR
• CT-R
• CTR1

Background

The Calcitonin Receptor inhibits bone resorption. This receptor is expressed during development and is involved in morphogenesis. Three alternatively spliced Calcitonin Receptor isoforms have been identified. In addition to binding calcitonin, the Calcitonin Receptor can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes. The Calcitonin Receptor has been reported in artery, blood, bone, brain, kidney, lung, placenta, prostate, skeletal muscle, and thyroid. ESTs have been isolated from bone, embryo, kidney, and melanocyte/uterus/fetal heart libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CALCR
• Entrez:
  • 799(Human)
• Uniprot:
  • P30988(Human)