BMPR-II Antibody (73805)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
73805
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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Catalog# & Formulation Size Price

BMPR-II Antibody (73805) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human BMPR-II
Ala26-Ile151
Accession # Q13873
Specificity
Detects human BMPR-II in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross‑react with recombinant human (rh) BMP R-IA or rhBMPR-IB.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
BMPR2
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Reviewed Applications
Read 1 Review rated 4
using
MAB811 in the following application:

Publications
Read Publications using
MAB811 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BMPR-II Antibody (73805)

  • BMP type II receptor
  • BMP type-2 receptor
  • BMPR2
  • BMPR-2
  • BMPR3
  • BMPRII
  • BMPR-II
  • BMPR-IIprimary pulmonary hypertension 1
  • Bone morphogenetic protein receptor type II
  • bone morphogenetic protein receptor type-2
  • bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • BRK-3
  • EC 2.7.11
  • EC 2.7.11.30
  • FLJ41585
  • FLJ76945
  • PPH1BMR2
  • T-ALK
  • type II activin receptor-like kinase
  • type II receptor for bone morphogenetic protein-4

Background

Like other members of the TGF-beta superfamily, cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the binding to heteromeric complex of type I and type II serine-threonine kinase receptors. Both receptor types are required for the signl transduction. BMP receptor II (BMPR-II) is one of the five mammalian type II receptors (including TGF-beta R-II, ActR-II, ActR-IIB, BMPR-II and MISR-II) for the TGF-beta superfamily ligands. The type II receptors for TGF-beta and activin bind ligands with high affinity by itself. In contrast, BMPR-II binds BMP-2, BMP-4 and BMP-7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor. BMPR-II mRNA is widely expressed in fetal and adult tissues. Human and mouse BMPR-II are highly conserved sharing 97% sequence identity.

  1. Rosenzweig, B.L. et al. (1995) Proc. Natl. Acad. Sci. USA 92:7632.
  2. Beppu, H. et al. (1997) Biochem. Biophys. Res. Commun. 235:499.
  3. Kawabata, M. et al. (1998) Cytokine and Growth Factor Reviews 9:49.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for BMPR-II Antibody (MAB811)(5)

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 3 applications: ELISA Development, ICC, Western Blot.


Filter By Application
ELISA Development
(2)
ICC
(2)
Western Blot
(1)
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Human
(4)
Rat
(1)
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Showing Publications 1 - 5 of 5.
Publications using MAB811 Applications Species
V Veschi, LR Mangiapane, A Nicotra, S Di Franco, E Scavo, T Apuzzo, DS Sardina, M Fiori, A Benfante, ML Colorito, G Cocorullo, F Giuliante, C Cipolla, G Pistone, MR Bongiorno, A Rizzo, CM Tate, X Wu, S Rowlinson, LF Stancato, M Todaro, R De Maria, G Stassi Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant Oncogene, 2019;0(0):. 2019 [PMID: 31591478] (ICC, Human) ICC Human
LA Hurst, BJ Dunmore, L Long, A Crosby, R Al-Lamki, J Deighton, M Southwood, X Yang, MZ Nikolic, B Herrera, GJ Inman, JR Bradley, AA Rana, PD Upton, NW Morrell TNF? drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling Nat Commun, 2017;8(0):14079. 2017 [PMID: 28084316] (ELISA Development, Human) ELISA Development Human
Chaverneff F, Barrett J Casein kinase II contributes to the synergistic effects of BMP7 and BDNF on Smad 1/5/8 phosphorylation in septal neurons under hypoglycemic stress. J. Neurochem., 2009;109(3):733-43. 2009 [PMID: 19222702] (ICC, Rat) ICC Rat
Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J. Mol. Biol., 2008;381(4):1025-39. 2008 [PMID: 18621057] (ELISA Development, Human) ELISA Development Human
Dai J, Keller J, Zhang J, Lu Y, Yao Z, Keller ET Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism. Cancer Res., 2005;65(18):8274-85. 2005 [PMID: 16166304] (Western Blot, Human) Western Blot Human

Review for BMPR-II Antibody (MAB811) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Human.

Reviews using MAB811:
Filter by Applications
Flow
(1)
All Applications
Filter by Species
Human
(1)
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Images Ratings Applications Species Date Details
  4
reviewed by:
Verified Customer
Flow Human 02/25/2015
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Summary

ApplicationFlow Cytometry
Sample TestedSee PMID 19116903
SpeciesHuman

Blocking

Blocking DetailsSee PMID 19116903

Details

Detection NotesSee PMID 19116903

Comments

CommentsIndependent review from antibodyresource.comPublished in PMID 19116903

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Verified Customer
02/25/2015
Application: Flow
Species: Human

Bioinformatics

Gene Symbol BMPR2
Uniprot