BMPR-II Antibody (73805) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: WB
• Clone: 73805
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

BMPR-II Antibody (73805) [Alexa Fluor® 488] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human BMPR-II
  Ala26-Ile151
  Accession # Q13873
• Specificity: Detects human BMPR-II in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross‑react with recombinant human (rh) BMP R-IA or rhBMPR-IB.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BMPR-II Antibody (73805) [Alexa Fluor® 488]

• BMP type II receptor
• BMP type-2 receptor
• BMPR2
• BMPR-2
• BMPR3
• BMPRII
• BMPR-II
• BMPR-IIprimary pulmonary hypertension 1
• Bone morphogenetic protein receptor type II
• bone morphogenetic protein receptor type-2
• bone morphogenetic protein receptor, type II (serine/threonine kinase)
• BRK-3
• EC 2.7.11
• EC 2.7.11.30
• FLJ41585
• FLJ76945
• PPH1BMR2
• T-ALK
• type II activin receptor-like kinase
• type II receptor for bone morphogenetic protein-4

Background

Like other members of the TGF-beta superfamily, cellular responses to bone morphogenetic proteins (BMPs) have been shown to be mediated by the binding to heteromeric complex of type I and type II serine-threonine kinase receptors. Both receptor types are required for the signl transduction. BMP receptor II (BMPR-II) is one of the five mammalian type II receptors (including TGF-beta R-II, ActR-II, ActR-IIB, BMPR-II and MISR-II) for the TGF-beta superfamily ligands. The type II receptors for TGF-beta and activin bind ligands with high affinity by itself. In contrast, BMPR-II binds BMP-2, BMP-4 and BMP-7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor. BMPR-II mRNA is widely expressed in fetal and adult tissues. Human and mouse BMPR-II are highly conserved sharing 97% sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.