BMPR-IA/ALK-3 Antibody

Immunocytochemistry/Immunofluorescence: BMPR-IA/ALK-3 Antibody [24960002] - Locolization of GAK-1 on chromosomes in C. elegans germline. Antibody dilution 1:400. Data provided by Jinmin Gao, Ph.D, Department of Genetics, Harvard Medical School.

ELISA: BMPR-IA/ALK-3 Antibody [24960002]

Product Discontinued

BMPR-IA/ALK-3 Antibody Summary

• Immunogen: This antibody is specific for the N Terminus Region of the target protein.
• Specificity: This product is specific for BMPR1A.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: BMPR1A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 1:400
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
• Application Notes: This antibody is useful in ELISA, Immunofluorescence and Immunohistochemistry-Paraffin. Customers have reported succes in IF locolization of GAK-1 on chromosomes in C. elegans germline.

Reactivity Notes

C. elegans.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

Manufactured by SDIX's proprietary Genomic Antibody Technology™. GAT FAQs.

Alternate Names for BMPR-IA/ALK-3 Antibody

• ACVRLK310q23del
• ALK-3
• ALK3EC 2.7.11.30
• BMP type-1A receptor
• BMPR1A
• BMPR-1A
• BMPRIA
• BMPR-IA
• bone morphogenetic protein receptor type-1A
• bone morphogenetic protein receptor, type IA
• CD292 antigen
• CD292
• EC 2.7.11
• Serine/threonine-protein kinase receptor R5
• SKR5
• type II-like kinase 3

Background

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for BMPR-IA/ALK-3 Antibody (24960002)(2)

Publications using 24960002

• Garrison C, Lastwika K, Zhang Y et al. Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections With Obesity J Proteome Res. 2017-01-06 [PMID: 27769113] (MiAr)
  
  Details:
  Analysis is performed on plasma proteomic data to identify how obesity can alter pathways and to highlight the risk factor for disease in subjects with a high body mass index.
• Rho JH, Lampe PD. High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays J Proteome Res. 2013-05-03 [PMID: 23541305] (MiAr)
  
  Details:
  A novel method using antibody microarrays is used to detect autoantibody-antigen complexes that can potentially be useful for detection and characterization of diseases.

Bioinformatics

• Gene Symbol: BMPR1A
• Entrez:
  • 657(Human)
• Uniprot:
  • P36894()