beta Amyloid Antibody (AB42-5) [Alexa Fluor® 750]

• Applications: ELISA
• Clone: AB42-5
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

beta Amyloid Antibody (AB42-5) [Alexa Fluor® 750] Summary

• Immunogen: Recombinant protein to Fibrillar Amyloid β 1-42 peptide
• Specificity: Detects Human APP/Protease Nexin II (amino acids 1-11 of Amyloid beta ) in direct ELISAs.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Amyloid Precursor Protein (APP) is a type I transmembrane protein that is ubiquitously expressed on cell surfaces. It undergoes complex proteolytic processing and is cleaved by alpha-, beta-, and gamma-Secretases to generate soluble APP alpha, soluble APP beta, and Amyloid beta (A beta) fragments of several lengths. One of these fragments, A beta 42, generated by beta- and gamma-Secretase activities, has been implicated in Alzheimer's disease. Aberrantly high levels of this peptide form and accumulate in the brains of Alzheimer's disease patients to create the senile plaques characteristic of the disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.