Bcl-2 related protein A1 Antibody

Product Discontinued

Bcl-2 related protein A1 Antibody Summary

• Immunogen: Synthetic peptide surrounding amino acid 37 of human A1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: BCL2A1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.5 - 4 ug/ml

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2), 0.5% BSA, 30% Glycerol
• Preservative: 0.01% Thimerosal
• Concentration: 0.2 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Bcl-2 related protein A1 Antibody

• ACC-1
• ACC-2
• Bcl-2 related protein A1
• BCL2A1
• Bcl2L5
• Bcl2-L-5
• BCL2L5HBPA1
• Bcl-2-like protein 5
• BCL2-related protein A1
• Bfl-1
• BFL1bcl-2-related protein A1
• GRS
• GRSbcl2-L-5
• hematopoietic BCL2-related protein A1
• Hemopoietic-specific early response protein
• Protein BFL-1
• Protein GRS

Background

Bcl-2 related protein A1; also known as Bcl2A1 and Bfl1, is an anti-apoptotic Bcl-2 family member preferentially expressed in hematopoietic and endothelial cells (1). Bfl1 is involved in a variety of cellular activities such as embryonic development, homeostatis and tumorigenesis. Expression of Bfl1 is stimulated by NF-kB in response to inflammatory stimuli and is up-regulated by TNF-alpha, IL1-beta, IGF1, GMC-SF, CD40 and phorbol ester (2-3). Blf1 has also been shown to reduce the release of pro-apoptotic cytochrome c from the mitochondria, block caspase activation and suppress apoptosis induced by p53 (4-5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Bioinformatics

• Gene Symbol: BCL2A1
• Entrez:
  • 597(Human)
• Uniprot:
  • Q16548()