Bcl-2 related protein A1 Antibody (OTI3D10) [mFluor Violet 450 SE]

• Reactivity: Hu
• Applications: WB
• Clone: OTI3D10
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: mFluor Violet 450 SE

Bcl-2 related protein A1 Antibody (OTI3D10) [mFluor Violet 450 SE] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Full length human recombinant protein of human BCL2A1 (NP_004040) produced in E.coli.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: BCL2A1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP2-70246. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Bcl-2 related protein A1 Antibody (OTI3D10) [mFluor Violet 450 SE]

• ACC-1
• ACC-2
• Bcl-2 related protein A1
• BCL2A1
• Bcl2L5
• Bcl2-L-5
• BCL2L5HBPA1
• Bcl-2-like protein 5
• BCL2-related protein A1
• Bfl-1
• BFL1bcl-2-related protein A1
• GRS
• GRSbcl2-L-5
• hematopoietic BCL2-related protein A1
• Hemopoietic-specific early response protein
• Protein BFL-1
• Protein GRS

Background

Bcl-2 related protein A1; also known as Bcl2A1 and Bfl1, is an anti-apoptotic Bcl-2 family member preferentially expressed in hematopoietic and endothelial cells (1). Bfl1 is involved in a variety of cellular activities such as embryonic development, homeostatis and tumorigenesis. Expression of Bfl1 is stimulated by NF-kB in response to inflammatory stimuli and is up-regulated by TNF-alpha, IL1-beta, IGF1, GMC-SF, CD40 and phorbol ester (2-3). Blf1 has also been shown to reduce the release of pro-apoptotic cytochrome c from the mitochondria, block caspase activation and suppress apoptosis induced by p53 (4-5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: BCL2A1