BAI3 Antibody (409611) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 409611
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

BAI3 Antibody (409611) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human BAI3 in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BAI3 Antibody (409611) [Alexa Fluor™ Plus 647]

• BAI3
• brain-specific angiogenesis inhibitor 3
• dJ91B17.1 (brain-specific angiogenesis inhibitor 3)
• KIAA0550MGC133100

Background

Human BAI3 (brain-specific angiogenesis inhibitor 3) is a 177 kDa, 7-transmembrane (TM) member of the secretin receptor family. It is synthesized by neurons of the CNS and likely is a negative regulator of angiogenesis. BAI3 is 1498 amino acids (aa) in size. It contains three distinct regions; an N-terminal extracellular domain (ECD) (aa 25‑883), a 7-TM segment, and a C-terminal cytoplasmic region. The ECD contains four antiangiogenic TSP type1 repeats (aa 296‑508), and one GPS domain (aa 816‑867) that is likely used to cleave the ECD from the membrane-bound receptor. There is one alternate splice form that shows a deletion of aa 643‑665. Over aa 25‑880, human BAI3 shares 98% aa identity with mouse BAI3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.