ARHGEF3 Antibody

Product Discontinued

ARHGEF3 Antibody Summary

• Immunogen: ARHGEF3 (NP_062455, 33 a.a. ~ 143 a.a) partial recombinant protein with GST tag.EPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLK
• Specificity: ARHGEF3 - Rho guanine nucleotide exchange factor (GEF) 3
• Clonality: Polyclonal
• Host: Mouse
• Gene: ARHGEF3
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Antibody reactive against cell lysate for western blot. It has also been used for ELISA.

Reactivity Notes

Human. Other species not tested.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Unpurified antisera so the specific antibody concentration is unknown. Contains 50% glycerol.
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for ARHGEF3 Antibody

• DKFZP434F2429
• Exchange factor found in platelets and leukemic and neuronal tissues
• FLJ98126
• MGC118905
• Rho guanine nucleotide exchange factor (GEF) 3
• rho guanine nucleotide exchange factor 3,59.8 kDA protein
• RhoGEF protein
• XPLNXPLN

Background

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ARHGEF3 Antibody (H00050650-A01)(1)

Publication using H00050650-A01

• D'Amato L, Dell'Aversana C, Conte M et al. ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias. Epigenetics 2014-12-12 [PMID: 25494542]

Bioinformatics

• Gene Symbol: ARHGEF3
• Entrez:
  • 50650(Human)
• Uniprot:
  • NP_062455(Human)