Apolipoprotein B/ApoB Antibody

Product Discontinued

Apolipoprotein B/ApoB Antibody Summary

• Immunogen: Made to Human APOLIPOPROTEIN B
• Specificity: Recognizes human apolipoprotein B.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: APOB
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Immunodiffusion

Reactivity Notes

Cross reacts with Guinea Pig, Pig and Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Glycine Buffered Saline (pH 7.4), 0.01% Benzamidine, 0.1% EACA and 1.0mM EDTA
• Preservative: 0.09% Sodium Azide
• Purity: IgG purified

Alternate Names for Apolipoprotein B/ApoB Antibody

• Apo B-100
• APOB
• ApoB-100
• ApoB-48
• apolipoprotein B (including Ag(x) antigen)
• Apolipoprotein B
• apolipoprotein B-100
• apolipoprotein B48
• FLDB
• LDLCQ4
• mutant Apo B 100

Background

Apolipoprotein B consists of a single polypeptide chain with a molecular weight of 549 kDa and is mostly synthesized in the liver. It is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. Normal plasma apolipoprotein B levels are around 800mg/L. At least 9 distinct polymorphic forms of apolipoproteins are known. The apolipoproteins act as stabilizers of the intact lipoprotein particles. Quantitative measurements of HDL, LDL and VLDL particles in human serum are often used to estimate an individuals' relative risk of coronary heart disease. In addition, quantitative immunological measurements of certain apolipoproteins (especially A-1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL). This apo-lipoprotein antibody is derived from human plasma by density gradient ultracentrifugation and HPLC.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: APOB
• Entrez:
  • 338(Human)
• Uniprot:
  • P04114()