APEX2 Antibody

Product Discontinued

APEX2 Antibody Summary

• Immunogen: APEX2 (NP_055296.2, 1 a.a. ~ 518 a.a) full-length human protein.MLRVVSWNINGIRRPLQGVANQEPSNCAAVAVGRILDELDADIVCLQETKVTRDALTEPLAIVEGYNSYFSFSRNRSGYSGVATFCKDNATPVAAEEGLSGLFATQNGDVGCYGNMDEFTQEELRALDSEGRALLTQHKIRTWEGKEKTLTLINVYCPHADPGRPERLVFKMRFYRLLQIRAEALLAAGSHVIILGDLNTAHRPIDHWDAVNLECFEEDPGRKWMDSLLSNLGCQSASHVGPFIDSYRCFQPKQE
• Specificity: APEX2 - APEX nuclease (apurinic/apyrimidinic endonuclease) 2,
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: APEX2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot 1:500
• Application Notes: Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control. It has also been used for immunofluorescence.

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for APEX2 Antibody

• AP endonuclease 2
• APE2
• APEX nuclease (apurinic/apyrimidinic endonuclease) 2
• APEX nuclease 2
• APEXL2
• Apurinic-apyrimidinic endonuclease 2
• DNA-(apurinic or apyrimidinic site) lyase 2
• DNA-apurinic or apyrimidinic site lyase 2
• EC 3.1
• EC 4.2.99.18
• XTH2

Background

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: APEX2
• Entrez:
  • 27301(Human)
• Uniprot:
  • NP_055296.2(Human)