APEX2 Products

Description

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). [provided by RefSeq]

Bioinformatics

Entrez	27301 Human
Uniprot	NP_055296 Human NP_055296 Human NP_055296.2 Human NP_055296.2 Human Q9UBZ4 Human Q9UBZ4 Human
Product By Gene ID	27301
Alternate Names	AP endonuclease 2 APE2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 APEX nuclease 2 APEXL2 Apurinic-apyrimidinic endonuclease 2 DNA-(apurinic or apyrimidinic site) lyase 2 DNA-apurinic or apyrimidinic site lyase 2 EC 3.1 EC 4.2.99.18 XTH2