Recombinant Mouse alpha-Synuclein (Control) Protein

Images

 
SDS-Page: Recombinant Mouse alpha-Synuclein Protein [NBP2-61596] - SDS-PAGE of ~14 kDa active mouse recombinant alpha Synuclein protein aggregate. Lane 1: Molecular Weight Ladder (MW). Lane 2: Active alpha Synuclein ...read more
In vitro assay: Recombinant Mouse alpha-Synuclein Protein [NBP2-61596] - Active alpha synuclein aggregate seeds the formation of new alpha Synuclein aggregates from the pool of active monomers. Thioflavin T is a ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, In vitro, In vivo, PAGE, Bioactivity
Concentration
2 mg/ml

Order Details

Recombinant Mouse alpha-Synuclein (Control) Protein Summary

Description
Active Mouse Recombinant Alpha Synuclein Protein Aggregate (pre-formed fibrils). NCBI Accession #: NP_001035916.1.

Source: E. coli

Amino Acid Sequence:

MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQE GILEDMPVDPGSEAYEMPSEEGYQDYEPEA
Details of Functionality
Endogenous alpha-synuclein phosphorylation. 100 uM alpha synuclein protein monomer seeded with 10 nM alpha synuclein protein aggregate in 25 uM Thioflavin T (PBS pH 7.4,100 ul reaction volume) generated an increased fluorescence intensity after incubation at 37 degrees C, being shaken at 600 rpm for 24 hours. Fluorescence was measured by excitation at 450 nm and emissionat 485 nm on a Molecular Devices Gemini XPS microplate reader.
Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
SNCA
Purity
>95%, by SDS-PAGE

Applications/Dilutions

Theoretical MW
14.46 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at -80C in the dark. Avoid freeze-thaw cycles.
Buffer
PBS
Concentration
2 mg/ml
Purity
>95%, by SDS-PAGE

Alternate Names for Recombinant Mouse alpha-Synuclein (Control) Protein

  • alpha-Synuclein
  • Lewy body) 4
  • MGC110988
  • NACP
  • non A-beta component of AD amyloid
  • Non-A beta component of AD amyloid
  • Non-A4 component of amyloid precursor
  • non-A4 component of amyloid
  • PARK1
  • PARK4
  • SNCA
  • synuclein, alpha (non A4 component of amyloid precursor)
  • Synuclein-alpha

Background

Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals. Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus. Functionally, it has been shown to significantly interact with tubulin, and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory. SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for alpha-Synuclein Recombinant Protein (NBP2-61596). (Showing 1 - 1 of 1 FAQ).

  1. I'm looking for an alpha-Synuclein antibody with an epitope located in the first half (N-terminus) of the protein - preferably a monoclonal antibody. Can you help me with that?
    • Please take a look at NB110-57475. It has been validated for human, rat and mouse and the applications ICC and WB and the epitope it detects is in the N terminal.

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Bioinformatics Tool for alpha-Synuclein Recombinant Protein (NBP2-61596)

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Bioinformatics

Gene Symbol SNCA