alpha-Sarcoglycan Antibody (769109) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: WB
• Clone: 769109
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

alpha-Sarcoglycan Antibody (769109) [Alexa Fluor® 405] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human α-Sarcoglycan
  Gln24-Ala290 (predicted)
  Accession # Q16586
• Specificity: Detects human alpha -Sarcoglycan in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for alpha-Sarcoglycan Antibody (769109) [Alexa Fluor® 405]

• 50-DAG
• Adhalin
• ADL
• alphaSarcoglycan
• alpha-Sarcoglycan
• DAG2
• DMDA2
• DMDA250kD DAG
• Dystroglycan-2
• LGMD2D
• LGMD2Dalpha (50kD dystrophin-associated glycoprotein)
• sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
• SCARMD1
• SGCA

Background

Alpha-sarcoglycan is one of six known sarcoglycans, which are type I ( alpha - and epsilon -) or type II ( beta -, gamma -, δ- or zeta -) transmembrane glycoproteins. Sarcoglycans alpha and gamma are expressed exclusively in the sarcoplasmic reticulum in skeletal and cardiac muscle, while others are more widely expressed. Sarcoglycans form heterotetrameric, pentameric and hexameric membrane glycoprotein complexes (SGC). SGC interacts laterally with the dystroglycan complex, and both complexes are components of the dystrophin-associated glycoprotein complex (DGC), which forms a link between the cytoskeleton and the extracellular matrix. Mutations in sarcoglycans are associated with recessive autosomally inherited limb-girdle muscular dystrophy. Human alpha -sarcoglycan shares 90% amino acid sequence identity with mouse and rat alpha -sarcoglycan within the extracellular domain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.