Alpha Fodrin Antibody (AA6)

• Reactivity: Hu, Rt, Ch, Gp, Rb
• Applications: WB, ELISA, IHC
• Clone: AA6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: 0.1 mg/ml

Alpha Fodrin Antibody (AA6) Summary

• Description: Novus Biologicals Mouse Alpha Fodrin Antibody (AA6) (NBP1-42321) is a monoclonal antibody validated for use in IHC, WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Chicken red blood cell membranes purified by hypotonic lysis and mechanical enucleation
• Specificity: Specific to the 240 kD a-fodrin molecule of all mammalian nonerythroid cells and chicken a-spectrin.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: SPTAN1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Western Blot 1:1000
• Application Notes: Immunohistochemical stainings on frozen sections, western blotting and other immunoassays for cellular and tumor biology.Working dilution in western blotting is at least 1:1000.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS, 1% BSA
• Preservative: 0.1% Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Protein A or G purified

Alternate Names for Alpha Fodrin Antibody (AA6)

• Alpha-II spectrin
• EIEE5
• FLJ17738
• FLJ44613
• Fodrin alpha chain
• NEAS
• spectrin alpha chain, brain
• spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
• Spectrin, non-erythroid alpha chain
• SPTA2

Background

SPTAN1/Alpha II-spectrin is one of two polypeptide chains (alpha and beta) that are part of the fodrin tetramer. Fodrin functions to link actin filaments to the plasma membrane and is a major neuronal cytoskeletal protein. Fodrin has been linked to neurogenerative and autoimmune diseases. Alternate names for SPTAN1/Alpha II-spectrin include alpha-fodrin, spectrin alpha chain brain, spectrin non-erythroid alpha chain, fodrin alpha chain, SPTA2, and FLJ44613.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SPTAN1