alpha-1B Adrenergic R/ADRA1B Antibody - BSA Free

Immunohistochemistry-Paraffin: alpha-1B Adrenergic R/ADRA1B Antibody [NLS697] - Analysis of anti-ADRA1B antibody with human adrenal, medulla.

• Reactivity: Hu, Mu, Rt, Bv, Ca, Ha, Pm, Pm
• Applications: IHC, IHC-P
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

alpha-1B Adrenergic R/ADRA1B Antibody - BSA Free Summary

• Immunogen: Synthetic 20 amino acid peptide from C-terminus of human alpha-1B Adrenergic R/ADRA1B.
• Epitope: C-Terminus
• Specificity: Human ADRA1B. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PLEKHG5 (45%).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADRA1B
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 11 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (100%), Bat (85%), Opossum (80%), Platypus (80%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Notes

Product can be stored undiluted at 4C for up to 1 month.

Alternate Names for alpha-1B Adrenergic R/ADRA1B Antibody - BSA Free

• a-1B AdrenergicR
• ADRA1
• ADRA1B
• adrenergic, alpha-1B-, receptor
• alpha-1B Adrenergic R
• alpha-1B adrenergic receptor
• alpha1B AdrenergicR
• Alpha-1B adrenoceptor
• Alpha-1B adrenoreceptor
• alpha-1B-adrenergic receptor
• ALPHA1BAR

Background

The alpha-1b adrenoceptor is an Adrenergic Receptor that causes contraction of smooth muscle cells and thereby controls vascular tone, blood pressure, and accelerates the development of atherosclerosis. Decreased alpha-1b adrenoceptor is associated with benign prostatic hyperplasia (BPH). This adrenergic receptor also acts as a proto-oncogene when transfected into cell lines where constitutive activation of the receptor induces neoplastic transformation. The alpha-1b adrenoceptor has been documented in adrenal, aorta, blood, various brain regions, eye, heart, kidney, liver, prostate, spinal cord, and spleen. ESTs have been isolated from kidney (normal and cancer) and lung carcinoma libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for alpha-1B Adrenergic R/ADRA1B Antibody (NLS697)(3)

Publications using NLS697

• Williams LM, Qi Z, Batai K et al. A locus on chromosome 5 shows African ancestry-limited association with alloimmunization in sickle cell disease Blood Adv 2018-12-26 [PMID: 30578281] (IHC-P, Human)
• Karabacakb Or, Sener Nc, Yilmazer D. Alpha Adrenergic Receptors In Renal Pelvis And Calyces: Can Rat Models Be Used? Int Braz J Urol 2014-12-16 [PMID: 25498280] (IHC-P, Rat)
• Karabacak OR, Yilmazer D, Ozturk U et al. The presence and distribution of alpha adrenergic receptors in human renal pelvis and calyces. Urolithiasis. 2013-10-01 [PMID: 23877383]
  
  Details:
  ADRA 1A (IMG-71129), ADRA1B (IMG-71127) and ADRA 1D (IMG-71130).

Bioinformatics

• Gene Symbol: ADRA1B
• Entrez:
  • 147(Human)
• Uniprot:
  • P35368()