ALK-1 Antibody (MM0015-8G33) - Azide and BSA Free

Immunohistochemistry-Paraffin: ALK Antibody (MM0015-8G33) [NB110-85462] - Formalin fixed and paraffin embedded human placental tissue section is subjected to IHC with NB110-85462.

Product Discontinued

ALK-1 Antibody (MM0015-8G33) - Azide and BSA Free Summary

• Immunogen: human TGF RI (ALK1) extra-cellular domain
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Mouse
• Gene: ACVRL1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:200-1:800

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with sterilized PBS to a final concentration of 0.2 mg/ml.

Alternate Names for ALK-1 Antibody (MM0015-8G33) - Azide and BSA Free

• activin A receptor type II-like 1
• activin A receptor, type II-like kinase 1
• Activin receptor-like kinase 1
• ACVRL1
• ACVRLK1ORW2
• ALK1
• ALK-1
• ALK1TGF-B superfamily receptor type I
• EC 2.7.11
• HHT
• HHT2EC 2.7.11.30
• serine/threonine-protein kinase receptor R3
• SKR3
• TSR-I

Background

LTK, ALK and Ros have been identified as receptor tyrosine kinases having sequence similarity to the insulin receptor subfamily of kinases. LTK, leukocyte tyrosine kinase, is expressed in murine B lymphocyte precursors and has also been found in forebrain neurons. ALK, anaplastic lymphoma kinase, is normally highly expressed specifically in the nervous system. A truncated form containing the catalytic domian of ALK is expressed as the result of a translocation occuring in many non-Hodgkin's lymphomas. The c-Ros gene was originally identified in mutant form as an oncogene. Ros is normally expressed in a small number of epithelial cell types and may play a role in epithelial development.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ACVRL1
• Entrez:
  • 94(Human)