Airway Trypsin-like Protease/HAT/TMPRSS11D Antibody (337029)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
337029
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price

Airway Trypsin-like Protease/HAT/TMPRSS11D Antibody (337029) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Airway Trypsin-like Protease/HAT
Ala42-Ile418
Accession # O60235
Specificity
Detects human Airway Trypsin-like Protease/HAT in direct ELISAs and Western blots. Recognizes the catalytic-domain of recombinant human HAT.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TMPRSS11D
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Publications
Read Publication using
MAB2695 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Airway Trypsin-like Protease/HAT/TMPRSS11D Antibody (337029)

  • airway trypsin like protease
  • Airway trypsin-like protease
  • EC 3.4.21
  • EC 3.4.21.-
  • HAT
  • MGC150587
  • MGC150588
  • TMPRSS11D
  • transmembrane protease serine 11D
  • transmembrane protease, serine 11D

Background

Human Airway Trypsin‑like protease (HAT), also known as Transmembrane Protease, Serine 11D (TMPRSSIID), is a type II transmembrane serine protease that is expressed in the cells of the submucosal serous glands of the bronchi and trachea (1‑3). The deduced sequence predicts a short cytoplasmic tail (aa 120), a transmembrane domain (aa 21‑41), and an ectodomain consisting of a SEA domain (aa 44‑164) and a catalytic domain (aa 187‑418). The single‑chain precursor can be converted into a disulfide‑linked two‑chains, one of which corresponds to the catalytic domain. HAT was initially purified from the sputum of patients with chronic airway diseases (1). HAT has been shown to induce PAR‑2 mediated IL‑8 release in psoriasis vulgaris and increase mucin expression in airway epithelial cells (4, 5). The amino acid sequence of human HAT is 99%, 79%, and 67% identical to that of chimpanzee, canine and rat/mouse.

  1. Yasuoka, S. et al. (1997) Am. J. Respir. Cell Mol. Biol. 16:300.
  2. Yamaoka, K. et al. (1998) J. Biol. Chem. 273:11895.
  3. Hooper, J.D. et al. (2001) J. Biol. Chem. 276:857.
  4. Iwakiri, K. et al. (2004) J. Invest. Dermatol. 122:937.
  5. Chokki, M. et al. (2004) Am. J. Respir. Cell Mol. Biol. 30:470.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Airway Trypsin-like Protease/HAT/TMPRSS11D Antibody (MAB2695)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-P.


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IHC-P
(1)
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