Airway Trypsin-like Protease/HAT/TMPRSS11D Antibody (337029) [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: WB
• Clone: 337029
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

Airway Trypsin-like Protease/HAT/TMPRSS11D Antibody (337029) [Alexa Fluor® 532] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Airway Trypsin-like Protease/HAT
  Ala42-Ile418
  Accession # O60235
• Specificity: Detects human Airway Trypsin-like Protease/HAT in direct ELISAs and Western blots. Recognizes the catalytic-domain of recombinant human HAT.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Airway Trypsin-like Protease/HAT/TMPRSS11D Antibody (337029) [Alexa Fluor® 532]

• airway trypsin like protease
• Airway trypsin-like protease
• EC 3.4.21
• EC 3.4.21.-
• HAT
• MGC150587
• MGC150588
• TMPRSS11D
• transmembrane protease serine 11D
• transmembrane protease, serine 11D

Background

Human Airway Trypsin-like protease (HAT), also known as Transmembrane Protease, Serine 11D (TMPRSSIID), is a type II transmembrane serine protease that is expressed in the cells of the submucosal serous glands of the bronchi and trachea (1-3). The deduced sequence predicts a short cytoplasmic tail (aa 120), a transmembrane domain (aa 21-41), and an ectodomain consisting of a SEA domain (aa 44-164) and a catalytic domain (aa 187-418). The single-chain precursor can be converted into a disulfide-linked two-chains, one of which corresponds to the catalytic domain. HAT was initially purified from the sputum of patients with chronic airway diseases (1). HAT has been shown to induce PAR-2 mediated IL-8 release in psoriasis vulgaris and increase mucin expression in airway epithelial cells (4, 5). The amino acid sequence of human HAT is 99%, 79%, and 67% identical to that of chimpanzee, canine and rat/mouse.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • O60235()