AICL/CLEC-2B Antibody (1064935) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: Flow
• Clone: 1064935
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

AICL/CLEC-2B Antibody (1064935) [Alexa Fluor® 488] Summary

• Immunogen: Chinese Hamster Ovary cell line, CHO-derived human AICL/CLEC-2B
  Lys26-His149
  Accession # Q92478
• Specificity: Detects human AICL/CLEC-2B in direct ELISA.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for AICL/CLEC-2B Antibody (1064935) [Alexa Fluor® 488]

• Activation-induced C-type lectin
• AICL
• AICLC-type lectin superfamily member 2
• CLEC2B
• CLEC-2B
• CLECSF2
• CLECSF2IFN-alpha-2b-inducing-related protein 1
• C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 2 (activation-induced)
• C-type lectin domain family 2 member B
• C-type lectin domain family 2, member B
• HP10085
• IFN-alpha2b-inducing related protein 1
• IFNRG1

Background

Activation-induced C-type lectin (AICL), also known as CLEC2B, is a 30-35 kDa variably glycosylated type-2 transmembrane member of the C-type lectin-like receptor (CTLR) family. AICL belongs to the subgroup of CLEC2 proteins that also includes CLEC2A/KACL, CLEC2D/LLT, and CD69/CLEC2C, all of which are encoded by the natural killer gene complex (1). Human AICL contains a single C-type lectin domain in its extracellular region and a 7 amino acid cytoplasmic tail (2). AICL is expressed on monocytes, macrophages, and granulocytes (3), and it is upregulated on TLR-activated monocytes and IL-12 + IL-18 activated NK cells (3, 4). AICL is an activating receptor that triggers TNF production by monocytes (3). It binds to NKp80 on NK cells, resulting in NK cell mediated lysis of the AICL expressing monocyte (3). In addition, the AICL-NKp80 axis mediates interactions between activated and resting NK cells (4).

1. Li, Y. et al. (2014) Front. Immunol. 5:123.
2. Hamann, J. et al. (1997) Immunogenetics 45:295.
3. Welte, S. et al. (2006) Nat. Immunol. 7:1334.
4. Klimosch, S.N. et al. (2013) Blood 122:2380.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q92478()