Agrin Antibody (Agr-131)

Images

 
Immunohistochemistry-Paraffin: Agrin Antibody (Agr-131) [NBP1-19245] - Analysis of rat brain tissue using Agrin, mAb (Agr-131)

Product Details

Summary
Reactivity Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC-P
Clone
Agr-131
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Agrin Antibody (Agr-131) Summary

Immunogen
Recombinant rat agrin protein (carboxy-terminal fragment)
Specificity
Agrin (Agr-131)
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
AGRN
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Paraffin
Publications
Read Publication using NBP1-19245.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.2, containing 50% glycerol
Preservative
0.09% Sodium Azide
Purity
Protein G purified

Alternate Names for Agrin Antibody (Agr-131)

  • agrin proteoglycan
  • Agrin
  • AGRN

Background

Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites; increasing the predicted MW from 200kDa to ~600kDa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Agrin Antibody (NBP1-19245)(1)

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol AGRN
Entrez