Agrin Antibody (Agr-131)

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Product Details

Summary
Reactivity RtSpecies Glossary
Applications WB
Clone
Agr-131
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Agrin Antibody (Agr-131) Summary

Immunogen
Recombinant rat agrin protein (carboxy-terminal fragment)
Specificity
Agrin (Agr-131)
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
AGRN
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
Publications
Read Publication using NBP1-19245.

Reactivity Notes

Rat.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
Sodium Azide
Purity
Protein G purified

Alternate Names for Agrin Antibody (Agr-131)

  • agrin proteoglycan
  • Agrin
  • AGRN

Background

Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites; increasing the predicted MW from 200kDa to ~600kDa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Agrin Antibody (NBP1-19245)(1)

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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol AGRN
Entrez