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Agrin Products

Antibodies
Agrin Antibody [Unconjugated] ...
Agrin Antibody [Unconjugated]
AF550
550-AG) induces acetylcholine receptor clustering on chick myotubes in a dose-dependent manner (orange line). Acetylcholine Receptor Clustering elicited by Recom-binant Rat Agrin (0.016 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Rat Agrin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF550). The ND50 is typically 0.001-0.004 µg/mL." class="big_lightbox" target="_blank"> Neutralization Agrin Antibody [Unconjugated]
NL001) and counterstained with DAPI (blue). Specific staining was localized to basement membrane of epithelial cells in tubules and endothelial cells in glomeruli. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections." class="big_lightbox" target="_blank"> Immunohistochemistry Agrin Antibody [Unconjugated]
Species: Rt
Applications: WB, IHC, B/N, ELISA(Cap)
Host: Goat Polyclonal
Agrin Antibody - BSA Free
Agrin Antibody - BSA Free
NBP1-90209
Species: Hu, Mu
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
ELISA Kits
Mouse Agrin ELISA Kit (Colori ...
Mouse Agrin ELISA Kit (Colorimetric)
NBP2-66662
Species: Mu
Applications: ELISA
Human Agrin ELISA Kit (Chemil ...
Human Agrin ELISA Kit (Chemilumine...
NBP2-66661
Species: Hu
Applications: ELISA
Rat Agrin ELISA Kit (Colorime ...
Rat Agrin ELISA Kit (Colorimetric)
NBP2-66663
Species: Rt
Applications: ELISA
Proteins
Recombinant Rat Agrin Protein ...
Recombinant Rat Agrin Protein
550-AG
Species: Rt
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human Agrin Prote ...
Recombinant Human Agrin Protein, CF
6624-AG
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Mouse Agrin His-t ...
Recombinant Mouse Agrin His-tag Pr...
11573-AG
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites; increasing the predicted MW from 200kDa to ~600kDa.

Bioinformatics

Entrez Mouse
Rat
Human
Uniprot Rat
Product By Gene ID 375790
Alternate Names
  • agrin proteoglycan
  • agrin
  • AGRIN

Research Areas for Agrin

Find related products by research area and learn more about each of the different research areas below.

Extracellular Matrix
Neuroscience