WB, IHC, ELISA(Cap), NeutHost:
Species: Hu, Mu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Host: Mouse Monoclonal
Applications: RNAi, RNAi SP
Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites; increasing the predicted MW from 200kDa to ~600kDa.
Research Areas for Agrin
Find related products by research area and learn more about each of the different research areas below.Extracellular MatrixNeuroscience
Bioinformatics Tool for Agrin
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