ABCC9 Antibody

Product Discontinued

ABCC9 Antibody Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: QKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEP
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ABCC9
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1 - 4 ug/ml
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 31067750). Rat (88%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for ABCC9 Antibody

• ABC37
• ABCC9
• ATP-binding cassette, sub-family C (CFTR/MRP), member 9
• CMD1OATP-binding cassette transporter sub-family C member 9
• EC 3.6.3.44
• FLJ36852
• Sulfonylurea receptor 2
• sulfonylurea receptor 2A
• SUR2
• SUR2ATP-binding cassette sub-family C member 9

Background

The protein encoded by the ABCC9 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. No disease has been associated with this gene thus far. Alternative splicing of this gene results in several products, two of which result from differential usage of two terminal exons and one of which results from exon deletion. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ABCC9 Antibody (NBP1-84436)(2)

Publications using NBP1-84436

• Krawchuk M Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice Int J Mol Sci 2019-05-07 [PMID: 31067750] (Mouse)
• Vazquez-Sanchez AY, Hinojosa LM, Parraguirre-Martinez S et al. Expression of KATP channels in human cervical cancer: Potential tools for diagnosis and therapy. Oncol Lett 2018-05-01 [PMID: 29849783] (Human)

Bioinformatics

• Gene Symbol: ABCC9