p62/SQSTM1 Products

p62/SQSTM1 Antibody (2C11)
p62/SQSTM1 Antibody (2C11)
Species: Hu, Mu, Rt, Rb
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IP
Host: Mouse Monoclonal
p62/SQSTM1 Antibody (5H7E2)
p62/SQSTM1 Antibody (5H7E2)
Species: Hu, Pm
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
Human, Mouse, Rat p62/SQSTM1 ...
Human, Mouse, Rat p62/SQSTM1 ELISA...
Species: Hu, Mu, Rt
Applications: ELISA
p62/SQSTM1 Knockout 293T Cell ...
p62/SQSTM1 Knockout 293T Cell Lysate
Species: Hu
Applications: WB
p62/SQSTM1 Knockout HeLa Cell ...
p62/SQSTM1 Knockout HeLa Cell Lysate
Species: Hu
Applications: WB
p62/SQSTM1 Overexpression Lys ...
p62/SQSTM1 Overexpression Lysate
Species: Hu
Applications: WB
p62/SQSTM1 Blocking Peptide
p62/SQSTM1 Blocking Peptide
Species: Hu
p62/SQSTM1 Blocking Peptide
p62/SQSTM1 Blocking Peptide
Species: Hu
Applications: AC
Recombinant Human p62/SQSTM1 ...
Recombinant Human p62/SQSTM1 Protein
Species: Hu
Applications: WB, ELISA, PA, AP
Species: Hu
Applications: RNAi, RNAi SP


SQSTM1, also known as p62, encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. SQSTM1 functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for SQSTM1. Mutations in SQSTM1 result in sporadic and familial Paget disease of bone.


Uniprot Human
Product By Gene ID 8878
Alternate Names
  • P62
  • OSIL
  • ORCA
  • sequestosome-1
  • Ubiquitin-binding protein p62
  • phosphotyrosine independent ligand for the Lck SH2 domain p62
  • Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
  • EBI3-associated protein p60
  • p62B
  • ZIP3
  • p62
  • oxidative stress induced like
  • Paget disease of bone 3
  • A170
  • p60PDB3
  • EBI3-associated protein of 60 kDa
  • sequestosome 1

Research Areas for p62/SQSTM1

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Signal Transduction

PTMs for p62/SQSTM1

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Bioinformatics Tool for p62/SQSTM1

Discover related pathways, diseases and genes to p62/SQSTM1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Related p62/SQSTM1 Blog Posts

Check out the latest blog posts on p62/SQSTM1.
RNA-binding protein Staufen1 conspires with Atxn2 in stress granules to cause neurodegeneration by dysregulating RNA metabolism
By Jamshed Arslan Pharm.D. Spinocerebellar ataxia type 2 (SCA2) is a movement disorder characterized by neurodegeneration. The cause of this autosomal dominant disease is a mutation in the RNA processing gene Atxn2,...    Read more.
How a cell "reaches" out for help
By Christina Towers, PhD. Parkinson's disease is a debilitating neurodegenerative condition defined by the accumulation of alpha-synuclein-containing (alpha-SYN) intra-cytoplasmic inclusions, called Lewy bodies. The...    Read more.
Measuring Autophagic Flux with LC3 protein levels: The do's and don'ts
By Christina Towers, PhD. Autophagy is a dynamic cellular recycling process that can be influenced by many different external and internal stimuli. The most commonly used assay to measure autophagy is a western blot f...    Read more.
Crosstalk Between Oxidative Stress and Autophagy
By Christina Towers, PhD. Role of Reactive Species in Cellular FunctionOxidative stress is a byproduct of an imbalance between oxidants and antioxidants present in the cell resulting in dysfunctional redox signali...    Read more.
Lysosomal Dysfunction is Linked to Exosomal Secretion
By Christina Towers, PhD. Lysosomal Dysfunction and DiseaseLysosomes are highly acidic organelles that are critical for cellular function and indispensable for degradative pathways like autophagy and endocytosis....    Read more.
Nuclear LC3: Why is it there and what is it doing?
By Christina Towers, PhD. Cells use the complex process of autophagy to degrade and recycle cytoplasmic material.  There are over 20 proteins that have been implicated in this process and appropriately named core...    Read more.
Autophagy inhibition in pediatrics: One physician-scientist’s brave decision
By Christina Towers, PhD. The current time from when a discovery is first made on the bench to when that discovery might translate into an approved therapy in cancer patients is an astounding 10-15 years. Scientists...    Read more.
Cleaner gone bad: Autophagy regulates motor neuron loss in spinal muscular atrophy
By Jamshed Arslan Pharm.D. Neuromuscular disorders affect the peripheral nervous system and muscles. Spinal muscular atrophy (SMA) is one such incurable disease in which muscles fail to receive signals from the spi...    Read more.
CaMKII stimulates autophagic degradation of 'ID', a new frontier against cancer
By Yoskaly Lazo-Fernandez, PhD The field of Cancer Stem Cell (CSC) research has been gaining traction in recent years1. CSCs are a minority group of cells (usually about 1 in 10000) within solid tumors of hematolog...    Read more.
Brain size matters: MTOR regulates autophagy and number of cortical interneurons
By Jamshed Arslan Pharm.D. Interneurons transmit impulses between other neurons, in part, to facilitate the birth of neurons. Cortical interneurons themselves arise from the progenitors in the ventral telencephalon,...    Read more.
Key Targets in Apoptosis, Necroptosis, and Autophagy
Cell death/recycling pathways such as apoptosis, necroptosis, and autophagy are an integral part of the growth, development, homeostasis as well as the pathophysiology in the life of living organisms. These signaling pathways are highly regulated and...    Read more.
What are the major differences between Apoptosis, Necroptosis & Autophagy?
Apoptosis is a form of programmed cell death which is mediated by cysteine proteases called caspases. It is an essential phenomenon in the maintenance of homeostasis and growth of tissues, and it also plays a critical role in immune response. The ...    Read more.
Required proteins for p62/SQSTM1 regulation and a role for p62/SQSTM1 in neuronal autophagy
Autophagy is a crucial cellular process that clears the cell of protein aggregates, toxins, and damaged cell products. Accumulation of toxins, damaged cell products and unwanted proteins has been proven to play a role in aging and many forms of dis...    Read more.
ATG4C - A regulator of the early steps of autophagosome assembly
Autophagy is an important cellular process that maintains homeostasis by degrading and recycling damaged proteins and organelles. Autophagy receptors, such as p62/SQSTM1, recognize these intracellular cargo and mediate their engulfment by the doubl...    Read more.
p62/SQSTM1 - targeting ubiquitinated proteins for autophagic degradation
During autophagy ubiquitinated cargo or substrates are engulfed in a double-membrane autophagosome and transported to the lysosome for degradation. This process is important for maintaining cellular homeostasis and for degrading damaged organelles...    Read more.
LC3/LC3B - measuring autophagosome formation and autophagic flux
Microtubule-associated protein-1 light chain 3 (LC3/LC3B) is a ubiquitin-like protein involved in the formation of the autophagosome. It is homologous to the yeast Atg8 protein. Autophagosomes are important for the degradation and recycling of intr...    Read more.
p62/SQSTM1 (sequestosome 1)
p62/SQSTM1 (sequestosome 1) is ubiquitously-expressed cytoplasmic/adaptor protein. SQSTM1 functions as a signaling hub for various signal transduction pathways involved in apoptosis, cell differentiation, apoptosis, immune response, and K+ channel reg...    Read more.
Read more p62/SQSTM1 related blogs.