Ubiquitin Products

Antibodies
Ubiquitin Antibody (1001C) [U ...
Ubiquitin Antibody (1001C) [Unconj...
A-101
Species: Multi
Applications: WB, ICC
Host: Rabbit Monoclonal
Ubiquitin Antibody (1002A) [U ...
Ubiquitin Antibody (1002A) [Unconj...
MAB8595
Species: Hu
Applications: WB
Host: Rabbit Monoclonal
Ubiquitin Antibody (Ubi-1)
Ubiquitin Antibody (Ubi-1)
NB300-130
Species: Hu, Mu, Rt, Bv, Ce, Ch, Dr, Pl
Applications: WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P
Host: Mouse Monoclonal
Lysates
Ubiquitin Overexpression Lysa ...
Ubiquitin Overexpression Lysate (N...
NBL1-15568
Applications: WB
Ubiquitin Overexpression Lysa ...
Ubiquitin Overexpression Lysate (D...
H00006233-T02
Applications: WB
Proteins
Ubiquitin Full Length Recombi ...
Ubiquitin Full Length Recombinant ...
NBP1-42465
Species: Hu
Applications: WB, PAGE
Ubiquitin Partial Recombinant ...
Ubiquitin Partial Recombinant Protein
H00006233-Q01
Species: Hu
Applications: WB, ELISA, PA
Ubiquitin Recombinant Protein ...
Ubiquitin Recombinant Protein
H00006233-P02
Species: Hu
Applications: WB, ELISA, PA
RNAi
Ubiquitin RNAi
Ubiquitin RNAi
H00006233-R01
Species: Hu

Description

Ubiquitin is a highly conserved protein of approximately 8.5kDa molecular weight, which has a normal role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C-terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.

Bioinformatics

Entrez Human
Human
Mouse
Rat
Bovine
Uniprot Human
Human
Human
Human
Human
Human
Bovine
Product By Gene ID 6233
Alternate Names
  • RPS27A
  • UBA52
  • UBC
  • UBB ubiquitin B

Research Areas for Ubiquitin

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Autophagy
Cancer
Membrane Trafficking and Chaperones
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Protein Turnover
Ubiquitin Proteasome Pathway

PTMs for Ubiquitin

Learn more about PTMs related to Ubiquitin.

Cleavage
Methylation

Bioinformatics Tool for Ubiquitin

Discover related pathways, diseases and genes to Ubiquitin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Ubiquitin Blog Posts

Check out the latest blog posts on Ubiquitin.
PINK1: All work and no fun
The protein PINK1 is a mitochondrial-located serine/threonine kinase (PTK) that maintains organelle function and integrity. It not only protects organelles from cellular stress, but it also uses the selective auto-phagocytosis process for cleaning and...    Read more.
Ubiquitin-Mediated Degradation of Cellular Proteins: The Kiss of Death
Ubiquitin is an abundant and essential cellular 9-kd protein that is conserved across evolution from yeast to humans. Ubiquitin is used by cells as a covalent modifier of other proteins both to activate their function and to target them for degradatio...    Read more.
Using Ubiquitin Antibodies in Various Disease Research
Ubiquitin is a small, highly conserved protein which plays an important role in protein breakdown, covalently bonding to proteins to mark them for proteolytic degradation in a process called ubiquitination. Ubiquitin also binds to inclusion bodies (ac...    Read more.
The Heat is On: Heat Shock Proteins and the Link to Cancer
Novus Biologicals offers an extensive antibody catalog targeting heat shock proteins (HSPs). A large protein group covering a number of families, the HSPs are functionally related by their dramatic upregulation in response to stress. Stress triggers m...    Read more.
The Latest Research on IBR-type E3 Ubiquitin Ligases
E3 ubiquitin ligases are standards in most antibody catalogs. These proteins are essential to the process of ubiquitination, which is expressed in protein pathways throughout the body and is often linked to disease states. It is widely used as a bioma...    Read more.
Read more Ubiquitin related blogs.