TrkA Products

Antibodies
TrkA Antibody [Unconjugated]
TrkA Antibody [Unconjugated]
AF175
Species: Hu
Applications: WB, Flow, IHC, B/N, CyTOF-ready
Host: Goat Polyclonal
Formulation Catalog # Availability Price  
TrkA Antibody [Unconjugated]
TrkA Antibody [Unconjugated]
AF1056
Species: Rt
Applications: WB, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
TrkA Antibody (JJ084-04)
TrkA Antibody (JJ084-04)
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Monoclonal
ELISA Kits
Rat TrkA ELISA Kit (Colorimet ...
Rat TrkA ELISA Kit (Colorimetric)
KA1507
Species: Rt
Applications: ELISA
Lysates
TrkA Overexpression Lysate
TrkA Overexpression Lysate
NBL1-13834
Species: Hu
Applications: WB
TrkA Overexpression Lysate
TrkA Overexpression Lysate
NBL1-13833
Species: Hu
Applications: WB
TrkA Overexpression Lysate
TrkA Overexpression Lysate
NBL1-13835
Species: Hu
Applications: WB
Proteins
Recombinant Human TrkA Fc Chi ...
Recombinant Human TrkA Fc Chimera ...
175-TK
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Rat TrkA Fc Chime ...
Recombinant Rat TrkA Fc Chimera Pr...
1056-TK
Species: Rt
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Human TrkA His Ta ...
Recombinant Human TrkA His Tagged ...
9966-TK
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

The Trk proto-oncogene encodes a 140 kDa, membrane-spanning protein tyrosine kinase that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that Trk A binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of Trk A as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF (1). Trk A was found to be expressed in the nervous system and phosphorylated in response to NGF (Nerve Growth Factor). Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes (2). Trk A is expressed in neural and nonneuronal tissues. Like RET, Trk A is often activated by rearrangements that involve one of at least five other genes in papillary thyroid carcinoma (PTC) (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Rat
Product By Gene ID 4914
Alternate Names
  • EC 2.7.10.1
  • EC 2.7.10
  • TRK1-transforming tyrosine kinase protein
  • Neurotrophic tyrosine kinase receptor type 1
  • p140-TrkA
  • tyrosine kinase receptor A
  • Trk-A
  • TRKAOncogene TRK
  • MTChigh affinity nerve growth factor receptor
  • TRKTRK1
  • DKFZp781I14186
  • neurotrophic tyrosine kinase, receptor, type 1

Research Areas for TrkA

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cancer
Immunology
Neuroscience
Phospho-Specific
Protein Kinase

PTMs for TrkA

Learn more about PTMs related to TrkA.

Phosphorylation
Methylation
Reduction
Glycosylation
Acetylation

Bioinformatics Tool for TrkA

Discover related pathways, diseases and genes to TrkA. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related TrkA Blog Posts

Check out the latest blog posts on TrkA.
TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its...    Read more.
TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...    Read more.
Read more TrkA related blogs.