TrkA Products

Antibodies
TrkA Antibody [Unconjugated]
TrkA Antibody [Unconjugated]
AF175
Species: Hu
Applications: WB, Flow, IHC, Neut
Host: Goat Polyclonal
TrkA Antibody [Unconjugated]
TrkA Antibody [Unconjugated]
AF1056
Species: Rt
Applications: WB, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
TrkA Antibody (5B6)
TrkA Antibody (5B6)
NBP2-46266
Species: Hu
Applications: WB, IHC, IHC-P
Host: Mouse Monoclonal
ELISA Kits
TrkA ELISA Kit [HRP]
TrkA ELISA Kit [HRP]
KA1507
Species: Rt
Lysates
TrkA Overexpression Lysate (N ...
TrkA Overexpression Lysate (Native)
NBL1-13834
Applications: WB
TrkA Overexpression Lysate (N ...
TrkA Overexpression Lysate (Native)
NBL1-13833
Applications: WB
TrkA Overexpression Lysate (N ...
TrkA Overexpression Lysate (Native)
NBL1-13835
Applications: WB
Proteins
TrkA Recombinant Protein Anti ...
TrkA Recombinant Protein Antigen
NBP2-38265PEP
Species: Hu
Applications: AC
TrkA Recombinant Protein
TrkA Recombinant Protein
P3887
Species: Hu
Applications: Func, PAGE
RNAi
TrkA RNAi
TrkA RNAi
H00004914-R12
Species: Hu
TrkA RNAi
TrkA RNAi
H00004914-R11
Species: Hu
TrkA RNAi
TrkA RNAi
H00004914-R10
Species: Hu

Description

The Trk proto-oncogene encodes a 140 kDa, membrane-spanning protein tyrosine kinase that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that Trk A binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of Trk A as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF (1). Trk A was found to be expressed in the nervous system and phosphorylated in response to NGF (Nerve Growth Factor). Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes (2). Trk A is expressed in neural and nonneuronal tissues. Like RET, Trk A is often activated by rearrangements that involve one of at least five other genes in papillary thyroid carcinoma (PTC) (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Rat
Product By Gene ID 4914
Alternate Names
  • EC 2.7.10.1
  • EC 2.7.10
  • TRK1-transforming tyrosine kinase protein
  • Neurotrophic tyrosine kinase receptor type 1
  • p140-TrkA
  • tyrosine kinase receptor A
  • Trk-A
  • TRKAOncogene TRK
  • MTChigh affinity nerve growth factor receptor
  • TRKTRK1
  • DKFZp781I14186
  • neurotrophic tyrosine kinase, receptor, type 1

Research Areas for TrkA

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cancer
Immunology
Neuroscience
Phospho-Specific
Protein Kinase

PTMs for TrkA

Learn more about PTMs related to TrkA.

Phosphorylation
Methylation
Reduction
Glycosylation
Acetylation

Bioinformatics Tool for TrkA

Discover related pathways, diseases and genes to TrkA. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related TrkA Blog Posts

Check out the latest blog posts on TrkA.
TrkB: Bridging Ontogenesis and Oncogenesis
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. Interaction of brain-derived neurotrophic factor (BDNF) with its...    Read more.
TrkB: Docking for Neurotrophins and Beyond.
Tropomyosin receptor kinase B (TrkB) is a member of the Trk receptor tyrosine kinases family consisting of TrkA, TrkB and TrkC. The sequence of these family members is highly conserved. TrK's are activated by several neurotrophins, which are small pro...    Read more.
Read more TrkA related blogs.