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ABCA1 - The Caretaker for Cholesterol Transportation

The ATP-binding cassette transporter A1 (ABCA1) protein is a key gatekeeper for regulating intracellular cholesterol transport. It is one member of a large family of genes comprised of cAMP-dependent anion transporter cell membrane proteins. These important proteins regulate reverse cholesterol efflux from cells into the peripheral tissues via apolipoprotein A-1 (apo). ABCA1 in particular has a diverse expression profile and is most highly expressed in macrophages.

ABCG8: Cholesterol's Fate

The ATP-binding cassette (ABC) transporter genes are key gatekeeper molecules that regulate the amount of dietary cholesterol retained by the body. They are a multifamily comprised of cAMP-dependent anion transporter cell membrane proteins that monitor reverse cholesterol efflux from cells into the peripheral tissues via apolipoprotein A-I (Apo). ABCG8 is expressed at high levels in the liver and intestine.