PCSK9

The ATP-binding cassette (ABC) transporter genes are key gatekeeper molecules that regulate the amount of dietary cholesterol retained by the body. They are a multifamily comprised of cAMP-dependent anion transporter cell membrane proteins that monitor reverse cholesterol efflux from cells into the peripheral tissues via apolipoprotein A-I (Apo). ABCG8 is expressed at high levels in the liver and intestine.