Antibody catalog

The loading controls on our antibody database are widely used in gel electrophoresis and Western blotting studies. Products like the GAPDH antibody detect "housekeeping" proteins which are abundantly distributed in cells. This makes them useful for checking the even loading of gel samples, and the even transfer of proteins at the blotting stage. They also serve a purpose in quality control, by verifying reagents are working correctly, and in the standardization of experimental results.

Microglia are the resident macrophages of the central nervous system, and the first line of immune defense. Pioneering antibody research in the 1990's identified the Integrin beta 2 protein (also called ITGB2, complement receptor 3, CR3, CD18, and Mac-1) as one of the key proteins in the recruitment of microglial cells. The ITGB2 subunit A is commonly called CD11b, and antibodies to this subunit are widely used as microglial markers.

The HIF family are heterodimeric, oxygen-sensitive transcription factors comprising an alpha and beta subunit which are normally dissociated in normoxic conditions. Our antibody catalog contains products targeting all the Hypoxia Inducible Factor isoforms which have been identified in mammalian cells. These include HIF-2 alpha antibody reagents targeting both the entire protein and specific epitopes.

The hypoxia inducible factors are a family of heterodimeric transcription factors which are activated in response to lowered oxygen levels, or hypoxia. Although it may seem that HIF-1 alpha receives all the attention, other HIF antibodies, such as the HIF-2 alpha and HIF-1 beta antibody, are frequently used in clinical research as well.

Tubulin is a heterodimeric complex composed of alpha and beta subunits. Just like histones, tubulin can undergo post-translational modification, to affect cellular function. Novus Biologicals offers a large database of modified Tubulin antibody products.

SOX2 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which play a vital role in embryonic development. SOX2 antibody research has identified Sox2 as a key transcription factor in pluripotent stem cells. We at Novus Biologicals offer a number of top quality SOX2 products in our stem cell antibody catalog.

The Survivin antibody is widely used in apoptosis studies, and as a cellular marker. Today, biochemists have a wide range of Survivin antibody products to choose from, suitable for use in Western Blot, Chromatin Immunoprecipitation (ChIP), Immunofluorescence and similar assays.

We at Novus Biologicals place a lot of emphasis on the kinase signaling pathways. Kinases, or phosphotransferase enzymes play a key role in phosphorylation signaling. Over 500 human protein kinases have so far been discovered. They play essential roles in glucose metabolism, apoptosis, lipid transport, cell migration, cellular differentiation and other cellular functions.

The Hypoxia Inducible Factors (HIFs) are a family of mammalian transcription factors which are expressed in response to low cellular oxygen concentrations (hypoxia). Three human hypoxia inducible factors have been identified, HIF-1, HIF-2 and HIF-3, each having an alpha and a beta subunit.

Obesity, diabetes and metabolic disorders are dramatically on the increase, linked to disorders such as heart disease, stroke and cancer. To combat this, research groups are studying metabolism at both a cellular and a systemic level.