Antibodies

Caspase 9 (also termed ICE-LAP6, Mch6, Apaf-3) is a member of cysteine protease family of caspases and is encoded by the CASP9 gene in humans. Caspase-9 is involved in mitochondrial apoptosis pathway and is an initiator caspase.

Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all mammals. Similar to Caspase 3, Caspase-7 is an effector caspase and plays a key role in apoptotic execution.

Toll-like receptor 9 (TLR9) is a protein encoded by TLR9 gene in humans. It is also known as cluster of differentiation 289 (CD289) and is a member of TLR family.

Toll-like receptor 7 (TLR7) is a protein encoded by the TLR7 gene in humans and is a member of TLR family. TLRs controls host immune response against pathogens (e.g. viruses, bacteria and fungi) through recognition of pathogen-associated molecular patterns (PAMPs) which are specific to the microorganisms.

RAD51 is a recombinase protein encoded by RAD51 gene in humans. Human RAD51 family members are highly similar to bacterial RecA and yeast Rad51, both biochemically and structurally. It is a 339-amino acid protein that plays an important role in homologous recombination (HR) of DNA during double-strand break (DSB) repair.

Growth Associated Protein 43 (GAP43), also termed B-50, F1 or P-57, is a neuron-specific cytoplasmic protein encoded by the GAP-43 gene in humans. The expression of GAP 43 is associated with neural development and synaptic plasticity. A high level of GAP43 expression is observed in neuronal growth cones during development, at axonal regeneration after injury and is phosphorylated after long-term potentiation (1).

 Ovarian carcinoma is disease that eludes early diagnosis and has a high mortality rate. In a diagnosis of ovarian carcinoma, one of the most common problems is to distinguish between a primary ovarian and colorectal adenocarcinoma (1).

Actin is a ubiquitous and an essential component of the cytoskeleton, with critical roles in a wide range of cellular processes. It is abundant protein whose monomers polymerize into polarized actin filaments, within epithelial cells. Filamentous actin is concentrated at the plasma membrane where a wide variety of actin-associated proteins harness the potential and structure of actin filaments to moderate functions at the plasma membrane (1).

An important aspect of mitochondria maintenance includes biogenesis to replenish damaged and degraded mitochondrial structures. The regulation of mitochondrial biogenesis is very complex and numerous genes regulate and synchronize protein synthesis from the mitochondrial and nuclear genome.

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