IL12

The LAG3 protein belongs to the Ig superfamily and contains 4 extracellular Ig-like domains (D1-D4). This molecule plays an key role in the immune response through negative regulation of T-cell proliferation, function, and homeostasis. It is required for maximum natural and induced regulatory T-cell function. LAG3 is closely related to the T-cell co-receptor CD4, and like CD4, binds to MHC class II molecules - but with a significantly higher affinity. It is expressed exclusively in activated T- and natural killer (NK) lymphocytes.

Toll-like receptor 9 (TLR9) is a protein encoded by TLR9 gene in humans. It is also known as cluster of differentiation 289 (CD289) and is a member of TLR family.