TRAIL/TNFSF10 Products

Description

Apoptosis or programmed cell death is induced in cells by a group of death domain containing receptors. Binding of ligand to these receptors sends signals that activate members of the caspase family of proteases. The signals ultimately cause degradation of chromosomal DNA by activating DNase. TRAIL (TNF related apoptosis induced ligand) or Apo 2L initiates apoptosis of tumor cells by binding to either of its receptors, DR4 or DR5. These receptors consist of an extracellular TRAIL binding domain and a cytoplasmic "death domain". In addition, two decoy receptors for TRAIL have also been identified. These receptors, designated DcR1 and DcR2, lack the death domain. Binding of TRAIL to either of these receptors, therefore, does not transmit the death signal. Thus, these receptors represent a novel way of regulating cell sensitivity to a pro-apoptotic cytokine at the cell surface. TRAIL is expressed predominantly in spleen, lung, and prostate but also in many other tissues. TRAIL is a type II membrane protein from the TNF family. The human form of the protein is 281 amino acids in length, whereas the murine form is 291 amino acids. The two forms share 65% identity. Recombinant human TRAIL monomer has a molecular mass of approximately 21 kDa. Due to glycosylation, recombinant human TRAIL migrates as a 24 kDa protein in SDS PAGE.

Bioinformatics

Entrez	8743 Human
Product By Gene ID	8743
Alternate Names	Apo-2 ligand APO2L Apo-2Ltumor necrosis factor (ligand) family, member 10 APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta CD253 antigen CD253 Protein TRAIL TL2 TNF-related apoptosis-inducing ligand TNFSF10 TRAIL TRAILTNF-related apoptosis inducing ligand TRAIL tumor necrosis factor (ligand) superfamily, member 10 tumor necrosis factor ligand superfamily member 10

Research Areas for TRAIL/TNFSF10

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Death Receptor Signaling Pathway
Signal Transduction
Tumor Suppressors