VIP Antibody

Immunohistochemistry-Paraffin: VIP Antibody [NB100-65658] - Formalin fixed, paraffin embedded human pancreas stained with Rabbit anti Human vasoactive intestinal peptide.

Product Discontinued

VIP Antibody Summary

• Immunogen: Synthetic peptide corresponding to part of the native molecule conjugated to Keyhole limpet Haemocyanin.
• Localization: Secreted
• Specificity: NB100-65658 is specific for vasoactive intestinal peptide.In IHC-paraffin positive staining is seen in the ganglion cells in both the superficial and deep plexus of the wall on the human small bowel.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: VIP
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Reactivity Notes

Human. Based on sequence similarity, is expected to react with: Bovine, Dog, Horse, Mouse, Pig, Rhesus Monkey, Rat, Sheep.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein G purified

Alternate Names for VIP Antibody

• MGC13587
• PHM27
• vasoactive intestinal peptide
• VIP peptides
• VIP

Background

Vasoactive Intestinal Peptide (VIP), a 28 amino acid peptide originally isolated from porcine duodenum, is present not only in gastrointestinal tissues but also in neural tissues, possibly as a neurotransmitter, and exhibits a wide variety of biological actions. It belongs to the glucagon family, and in the duodenum is known to stimulate myocardial contractility, cause vasodilation, increase glycogenolysis, lower arterial blood pressure and relax the smooth muscle of trachea, stomach and gall bladder. Ectopic endocrine tumors secreting VIP (VIPomas) give rise to raised plasma levels of VIP and are associated with watery diarrhea, hypokalemia and achlorhydria syndrome. This antibody detects ganglion cells in both the superficial and deep plexus of the wall of the small bowel in human. The VIP producing tumors are usually neuroblastomas of endocrine tumors in the pancreas.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: VIP
• Entrez:
  • 7432(Human)
• Uniprot:
  • P01282(Human)