USP18 Antibody

Product Discontinued

USP18 Antibody Summary

• Immunogen: USP18 (CAK54503.1, 1 a.a. ~ 372 a.a) full-length human protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: USP18
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunoprecipitation
  • Western Blot
• Application Notes: This antibody is useful for Western Blot, Immunoprecipitation, Functional

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Serum
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for USP18 Antibody

• EC 3.1.2.15
• EC 3.4.19.-
• hUBP43
• ISG15-specific-processing protease
• ISG43
• ISG43UBP43
• ubiquitin specific peptidase 18
• ubiquitin specific protease 18
• ubl carboxyl-terminal hydrolase 18
• ubl thioesterase 18,43 kDa ISG15-specific protease
• Ubl thiolesterase 18
• UBP43
• USP18

Background

UBP43 (also known as ISG43, Ubl thiolesterase 18, ISG15-specific processing protease, 43 kDa ISG15-specific protease, ubiquitin specific protease 18 or USP18) is a member of the deubiquitinating protease family of enzymes, which removes ubiquitin adducts from a broad range of protein substrates. Deletion of the UBP43 gene in mouse leads to a massive increase of ISG15 conjugates in tissues indicating that UBP43 is a major ISG15-specific protease. UBP43 is the first ISG15-specific protease reported. Both ISG15 and UBP43 genes are known to be strongly induced by interferon, genotoxic stress, and viral infection. Thus UBP43 may be necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: USP18
• Uniprot:
  • CAK54503.1(Human)