UBR2 Antibody (PCRP-UBR2-1D12) [DyLight 650]

• Reactivity: Hu
• Applications: WB, Flow, ICC/IF, IHC, IP, MA
• Clone: PCRP-UBR2-1D12
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 650

UBR2 Antibody (PCRP-UBR2-1D12) [DyLight 650] Summary

• Immunogen: Recombinant full-length human UBR2 protein (Uniprot: Q8IWV8)
• Localization: Nucleus
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: UBR2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Protein Array
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for UBR2 Antibody (PCRP-UBR2-1D12) [DyLight 650]

• bA49A4.1
• C6orf133MGC71112
• chromosome 6 open reading frame 133
• dJ242G1.1
• dJ392M17.3
• DKFZp686C08114
• E3 ubiquitin-protein ligase UBR2
• EC 6.3.2.-
• KIAA0349FLJ36357
• N-recognin-2
• RP3-392M17.3
• ubiquitin protein ligase E3 component n-recognin 2
• Ubiquitin-protein ligase E3-alpha-2
• Ubiquitin-protein ligase E3-alpha-II

Background

Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: UBR2