UBR2 Products

Description

Position of the Chimera RNAi. The related RNAi products listed were designed from different accesion number but sharing the same RNAi sequence. Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	23304
Alternate Names	bA49A4.1 C6orf133MGC71112 chromosome 6 open reading frame 133 dJ242G1.1 dJ392M17.3 DKFZp686C08114 E3 ubiquitin-protein ligase UBR2 EC 6.3.2.- KIAA0349FLJ36357 N-recognin-2 RP3-392M17.3 ubiquitin protein ligase E3 component n-recognin 2 Ubiquitin-protein ligase E3-alpha-2 Ubiquitin-protein ligase E3-alpha-II