UBR2 Antibody (PCRP-UBR2-1D12) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Applications: WB, Flow, ICC/IF, IHC, IP, MA
• Clone: PCRP-UBR2-1D12
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

UBR2 Antibody (PCRP-UBR2-1D12) [Alexa Fluor™ Plus 647] Summary

• Immunogen: Recombinant full-length human UBR2 protein (Uniprot: Q8IWV8)
• Localization: Nucleus
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: UBR2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Protein Array
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for UBR2 Antibody (PCRP-UBR2-1D12) [Alexa Fluor™ Plus 647]

• bA49A4.1
• C6orf133MGC71112
• chromosome 6 open reading frame 133
• dJ242G1.1
• dJ392M17.3
• DKFZp686C08114
• E3 ubiquitin-protein ligase UBR2
• EC 6.3.2.-
• KIAA0349FLJ36357
• N-recognin-2
• RP3-392M17.3
• ubiquitin protein ligase E3 component n-recognin 2
• Ubiquitin-protein ligase E3-alpha-2
• Ubiquitin-protein ligase E3-alpha-II

Background

Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003 [PubMed 14585983]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: UBR2