Trypsin 1/PRSS1 Antibody (2C4) - BSA Free

Product Discontinued

Trypsin 1/PRSS1 Antibody (2C4) - BSA Free Summary

• Immunogen: Trypsin purified from human pancreatic tissue and adsorbed onto aluminum hydroxide gel (2)
• Specificity: Specific for human trypsin, trypsinogen and trypsin in complex with alpha-1-antitrypsin. Cross reacts weakly with bovine trypsin.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PRSS1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:8000
  • Western Blot 1:100-1:2000

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: 10mM Phosphate (pH 7.4) and 0.5M NaCl
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A or G purified

Alternate Names for Trypsin 1/PRSS1 Antibody (2C4) - BSA Free

• Beta-trypsin
• Cationic trypsinogen
• digestive zymogen
• DKFZp779A0837
• EC 3.4.21
• EC 3.4.21.4
• FLJ57296
• MGC120175
• MGC149362
• nonfunctional trypsin 1
• protease, serine, 1 (trypsin 1)
• PRSS1
• PTRYI
• Serine protease 1
• TRP1
• TRY1beta-trypsin
• TRY4
• Trygn16
• TRYP1
• Trypsin 1
• Trypsin I
• trypsin-1
• Trypsinogen 1
• trypsinogen A

Background

Trypsin is a 24 kDa enzyme of the serine proteinase family. It is produced in the pancreas as an inactive precursor, trypsinogen. The active enzyme is located in the gastrointestinal tract where it degrades proteins to large peptides. Trypsin predominantly cleaves proteins at the carboxyl side of the amino acids lysine and arginine. A common trypsin substrate is chymotrypsinogen which is cleaved to produce active chymotrypsin. High levels of immunoreactive trypsin in the bloodstream can indicate pancreatic malfunction and this indicator is used to screene for and diagnose Cystic Fibrosis (1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PRSS1