Troponin T type 1 (slow skeletal) Antibody (2G3) [DyLight 680]

Product Discontinued

Troponin T type 1 (slow skeletal) Antibody (2G3) [DyLight 680] Summary

• Immunogen: Human cardiac Troponin T.
• Specificity: Human cardiac Troponin T No cross reactivity with human skeletal Troponin T.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: TNNT1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Relevant Entrez Gene Numbers: NM_000363.4 Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Troponin T type 1 (slow skeletal) Antibody (2G3) [DyLight 680]

• ANMtroponin T, slow skeletal muscle
• FLJ98147
• MGC104241
• Slow skeletal muscle troponin T
• STNT
• TnTs
• TNTtroponin T1, skeletal, slow
• troponin T type 1 (skeletal, slow)
• troponin-T1, skeletal, slow

Background

Troponin T type 1 encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNNT1