Transgelin/TAGLN/SM22 alpha Antibody (SPM606) - IHC-Prediluted

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Immunohistochemistry-Paraffin: Transgelin/TAGLN/SM22 alpha Antibody (SPM606) - IHC-Prediluted [NBP2-48074] - Human Colon Carcinoma stained with Transgelin Monoclonal Antibody (SPM606)

Product Details

Summary
Reactivity Hu, Mu, Po, Pm, RbSpecies Glossary
Applications IHC, IHC-P
Clone
SPM606
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
IHC-Prediluted

Order Details

Transgelin/TAGLN/SM22 alpha Antibody (SPM606) - IHC-Prediluted Summary

Immunogen
Recombinant full-length human transgelin (TAGLN) protein.
Localization
Cytoplasmic
Specificity
This MAb recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TAGLN
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes.
Optimal dilution for a specific application should be determined.
Theoretical MW
22 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10 mM PBS with 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

The prediluted antibody does not require any mixing, dilution, reconstitution, or titration; the antibody is ready-to-use and optimized for staining.

Alternate Names for Transgelin/TAGLN/SM22 alpha Antibody (SPM606) - IHC-Prediluted

  • DKFZp686P11128
  • Protein WS3-10
  • SM22 alpha
  • SM2222 kDa actin-binding protein
  • SMCCDKFZp686B01212
  • Smooth muscle protein 22-alpha
  • TAGLN
  • TAGLN1
  • transgelin variant 2
  • Transgelin
  • WS3-10
  • WS3-10SM22-alpha

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-47689AF350
Alexa Fluor 405 NBP2-47689AF405
Alexa Fluor 488 NBP2-47689AF488
Alexa Fluor 532 NBP2-47689AF532
Alexa Fluor 594 NBP2-47689AF594
Alexa Fluor 647 NBP2-47689AF647
Alexa Fluor 700 NBP2-47689AF700
Alexa Fluor 750 NBP2-47689AF750
Allophycocyanin NBP2-47689APC
Biotin NBP2-47689B
DyLight 350 NBP2-47689UV
DyLight 405 NBP2-47689V
DyLight 488 NBP2-47689G
DyLight 550 NBP2-47689R
DyLight 594 NBP2-47689DL594
DyLight 650 NBP2-47689C
DyLight 680 NBP2-47689FR
DyLight 755 NBP2-47689IR
FITC NBP2-47689F
HRP NBP2-47689H
Janelia Fluor 549 NBP2-47689JF549
Janelia Fluor 646 NBP2-47689JF646
PE NBP2-47689PE
PerCP NBP2-47689PCP

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Bioinformatics

Gene Symbol TAGLN