Hu, Mu, Rt, RbApplications:
Hu, Mu, Rt, Bovine, PorcineApplications:
WB, ICC/IF, IHC, IHC-P, IPHost:
Species: Hu, Mu, Rt, Bv, Porcine
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Applications: B/N, Ctrl
In contrast to fast and slow skeletal muscle cells that fuse and terminally differentiate, smooth muscle cells are able to simultaneously proliferate and express lineage-restricted proteins. One of these proteins, expressed exclusively in smooth muscles, has been referred to as SM22-alpha, a 22 kDa protein with structural similarity to the vertebrate thin filament myofibrillar regulatory protein calponin and the Drosophila muscle protein mp20, neither of which play a direct role in the contractile apparatus.The protein is a transformation and shape-change sensitive actin cross-linking/geling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear.
Bioinformatics Tool for Transgelin/TAGLN/SM22 alpha
Discover related pathways, diseases and genes to Transgelin/TAGLN/SM22 alpha. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.