Transgelin/TAGLN/SM22 alpha Products

Description

In contrast to fast and slow skeletal muscle cells that fuse and terminally differentiate, smooth muscle cells are able to simultaneously proliferate and express lineage-restricted proteins. One of these proteins, expressed exclusively in smooth muscles, has been referred to as SM22-alpha, a 22 kDa protein with structural similarity to the vertebrate thin filament myofibrillar regulatory protein calponin and the Drosophila muscle protein mp20, neither of which play a direct role in the contractile apparatus.The protein is a transformation and shape-change sensitive actin cross-linking/geling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear.

Bioinformatics

Entrez	21345 Mouse 25123 Rat 6876 Human
Uniprot	AAH04927 Human AAH04927.1 Human NM_001001522 Human NM_003186 Human NP_001001522 Human NP_001001522.1 Human NP_003177.2 Human Q01995 Human
Product By Gene ID	6876
Alternate Names	DKFZp686P11128 Protein WS3-10 SM2222 kDa actin-binding protein SMCCDKFZp686B01212 Smooth muscle protein 22-alpha TAGLN1 transgelin variant 2 transgelin WS3-10SM22-alpha

Diseases related to Transgelin/TAGLN/SM22 alpha

Discover more about diseases related to Transgelin/TAGLN/SM22 alpha.

Neoplasms
Malignant Neoplasms
Carcinoma
Retinoblastoma
Cell Transformation, Neoplastic
Mammary Neoplasms
Adenocarcinoma
Malignant Neoplasm Of Breast
Malignant Paraganglionic Neoplasm
Neoplasm Metastasis
Malignant Squamous Cell Neoplasm
Cell Invasion
Carcinogenesis
Metastatic Malignant Neoplasm To The Lymph Node
Prostatic Neoplasms
Tissue Adhesions
Hyperplasia
Leukemia
Lymphoma
Adenoma

Pathways for Transgelin/TAGLN/SM22 alpha

View related products by pathway and learn more about each of the pathways below.

Cell Cycle
Cell Proliferation
Cell Growth
S Phase
Cell Cycle Arrest
Cell Differentiation
Senescence
Localization
Cell Death
Pathogenesis
G1 Phase
Oncogenesis
Reverse Transcription
Angiogenesis
Proteolysis
Cell Division
Smooth Muscle Cell Differentiation
Muscle Cell Differentiation
Transdifferentiation
Mitosis

PTMs for Transgelin/TAGLN/SM22 alpha

Learn more about PTMs related to Transgelin/TAGLN/SM22 alpha.

Phosphorylation
Cleavage
Acetylation
Methylation
Dephosphorylation
Ubiquitination
Biotinylation
Reduction

Bioinformatics Tool for Transgelin/TAGLN/SM22 alpha

Discover related pathways, diseases and genes to Transgelin/TAGLN/SM22 alpha. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.