TPMT Antibody

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Product Details

Summary
Product Discontinued
View other related TPMT Primary Antibodies

Order Details


    • Catalog Number
      NB100-2456
    • Availability
      Product Discontinued

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TPMT Antibody Summary

Immunogen
Synthetic peptide: C-DAFEERHKSWGID, representing the C Terminus of the human protein according to NP_000358.1
Clonality
Polyclonal
Host
Goat
Gene
TPMT
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Peptide ELISA detection limit 1:16000
Application Notes
Western blot: Preliminary experiments in Human Bone Marrow, Kidney, Liver and Testis lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
Positive Control
TPMT Lysate (NBL1-17222)

Reactivity Notes

Human. Expected to react based Mouse, Rat, Dog, Cow

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for TPMT Antibody

  • EC 2.1.1.67
  • S-adenosyl-L-methionine:thiopurine S-methyltransferase
  • Thiopurine methyltransferase
  • thiopurine S-methyltransferase

Background

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for TPMT Antibody (NB100-2456) (0)

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Additional TPMT Products

Bioinformatics Tool for TPMT Antibody (NB100-2456)

Discover related pathways, diseases and genes to TPMT Antibody (NB100-2456). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for TPMT Antibody (NB100-2456)

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Pathways for TPMT Antibody (NB100-2456)

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Bioinformatics

Gene Symbol TPMT
Entrez
Uniprot