TPMT Products

Antibodies
Lysates
TPMT Overexpression Lysate
TPMT Overexpression Lysate
NBL1-17222
Species: Hu
Applications: WB
Proteins
Recombinant Human TPMT Protei ...
Recombinant Human TPMT Protein
NBC1-18525
Species: Hu
Applications: PAGE
TPMT Recombinant Protein Anti ...
TPMT Recombinant Protein Antigen
NBP1-86032PEP
Species: Hu
Applications: AC

Description

TPMT encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 7172
Alternate Names
  • Thiopurine methyltransferase
  • S-adenosyl-L-methionine:thiopurine S-methyltransferase
  • EC 2.1.1.67
  • thiopurine S-methyltransferase

PTMs for TPMT

Learn more about PTMs related to TPMT.

Methylation
Reduction
Phosphorylation
Cleavage
Acetylation
Oxidation

Bioinformatics Tool for TPMT

Discover related pathways, diseases and genes to TPMT. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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