TMEM38B Antibody - BSA Free

Western Blot: TMEM38B Antibody [NBP1-77093] - Rat thymus tissue lysate with TMEM38B antibody at (A) 1 and (B) 2 ug/mL.

Immunohistochemistry-Paraffin: TMEM38B Antibody [NBP1-77093] - Mouse thymus tissue with TMEM38B antibody at 5 ug/mL.

Immunocytochemistry/ Immunofluorescence: TMEM38B Antibody - BSA Free [NBP1-77093] - Immunofluorescence of TMEM38B in mouse thymus tissue with TMEM38B antibody at 20 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

TMEM38B Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit TMEM38B Antibody - BSA Free (NBP1-77093) is a polyclonal antibody validated for use in IHC, WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38B. The immunogen is located within the last 50 amino acids of TMEM38B. Amino Acid Squence: VDVASDNVKKKHTKKNE
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TMEM38B
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/mL
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1-2 ug/ml
• Control Peptide:

  TMEM38B Peptide (NBP1-77093PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for TMEM38B Antibody - BSA Free

• bA219P18.1
• chromosome 9 open reading frame 87
• D4Ertd89e
• FLJ10493
• transmembrane protein 38BC9orf87
• TRIC-BTRICB
• trimeric intracellular cation channel type B

Background

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38B is expressed in most mammalian tissues, while TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Mice that were lacking only TMEM38B however, die shortly after birth due to respiratory failure and have lungs exhibiting severe histological defect and ultrastructural abnormalities in their alveolar type II epithelial cells, indicating that TMEM38B are essential for perinatal lung maturation. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TMEM38B
• Uniprot:
  • NP_060582(Human)