Thyroglobulin Antibody (5E6cc)

Product Discontinued

Thyroglobulin Antibody (5E6cc) Summary

• Immunogen: Hybridoma clone has been derived from hybridization of Sp2/0 myeloma cells with spleen cells of Balb/c mice immunized with Thyroglobulin from human thyroid gland.
• Localization: Secreted
• Specificity: Specifically recognizes human thyroglobulin and does not interfere with anti-thyroglobulin autoantibodies.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: TG
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Sandwich ELISA 1:100-1:2000
• Application Notes: Recommended pair for sandwich ELISA (capture-detection): NB110-8085 - NB110-8083

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS (pH 7.4)
• Preservative: 0.09% Sodium Azide
• Purity: Protein A purified

Alternate Names for Thyroglobulin Antibody (5E6cc)

• AITD3
• AITD3TGN
• cog
• TDH3
• Tg
• TGN
• Thyroglobulin

Background

The human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3.Thyroid disorders are, in large part, due to autoimmune origin, and anti-thyroglobulin autoantibodies were the first factor to be discovered. Anti-hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves' diseases), with the highest level observed in Hashimoto's thyroiditis. Anti-hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TG
• Entrez:
  • 7038(Human)