Thyroglobulin Antibody (12G9)

Product Discontinued

Thyroglobulin Antibody (12G9) Summary

• Immunogen: Thyroglobulin from human thyroid gland.
• Localization: Secreted
• Specificity: This does not interfere with anti-thyroglobulin autoantibodies.
• Isotype: IgM
• Clonality: Monoclonal
• Host: Mouse
• Gene: TG
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000

Reactivity Notes

Cross-reacts with Human, Mouse, Rat, Cow, Cat, Dog and Pig.Not yet tested in other species. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS (pH 7.4)
• Preservative: 0.09% Sodium Azide
• Purity: Protein G purified

Alternate Names for Thyroglobulin Antibody (12G9)

• AITD3
• AITD3TGN
• cog
• TDH3
• Tg
• TGN
• Thyroglobulin

Background

The human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti-thyroglobulin autoantibodies were the first factor to be discovered. Anti-hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves diseases), with the highest level observed in Hashimoto's thyroiditis. Anti-hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TG
• Entrez:
  • 7038(Human)
  • 21819(Mouse)
  • 24826(Rat)