TfR (Transferrin R) Antibody (7-1)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB110-8472
    • Availability
      Product Discontinued

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TfR (Transferrin R) Antibody (7-1) Summary

Immunogen
Recombinant full length protein (Human).
Localization
Cell Membrane and Secreted
Marker
Recycling Endosome Marker
Specificity
This reacts with human transferrin receptor.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
TFRC
Purity
Protein A purified
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Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Conjugate
Unconjugated
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Purity
Protein A purified

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000

Reactivity Notes

Cross-reacts with Human.Not yet tested in other species.

Alternate Names for TfR (Transferrin R) Antibody (7-1)

  • CD71 antigen
  • CD71
  • CD71TRFR
  • p90
  • T9
  • TfR (Transferrin R)
  • TfR (TransferrinR)
  • TfR
  • TFR1
  • TFRC
  • TR
  • transferrin receptor (p90, CD71)
  • transferrin receptor protein 1
  • TRFR

Background

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics Tool for TfR (Transferrin R) Antibody (NB110-8472)

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Research Areas for TfR (Transferrin R) Antibody (NB110-8472)

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Blogs on TfR (Transferrin R).

Transferrin and the blood brain barrier
Transferrin, an iron binding protein that facilitates iron uptake in cells, is an integral part of a mechanism that may introduce antibody therapies to the central nervous system. Currently, the brain’s ability to take in antibody therapies i...  Read full blog post.

Contact Information

Product PDFs

Bioinformatics

Gene Symbol TFRC
Entrez

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