Western Blot: TDG Antibody (622) [NBP2-43717] - RNAseq analysis showed that essential factors of the BER pathway were statistically significantly down-regulated (p<0.05) in 96-h induced Saos2- (i) and Li-Fraumeni- (ii) ...read more
Western Blot: TDG Antibody (622) [NBP2-43717] - Analysis of 293T mock transfected (-) or transfected with a construct expressing human TDG. 10 % SDS-PAGE TDG antibody dilution: 1:10000.
46 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Protein G purified
Alternate Names for TDG Antibody (622)
thymine-DNA glycosylaseG/T mismatch-specific thymine DNA glycosylase
Thymine DNA glycosylase is encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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