TAP2 Antibody

Immunohistochemistry-Paraffin: TAP2 Antibody [NBP1-40335] - Analysis of anti-TAP2 antibody with human thymus at concentration 10 ug/ml.

Product Discontinued

TAP2 Antibody Summary

• Immunogen: Synthetic peptide from human TAP2.
• Specificity: Amino acids 689 to 703 of human TAP2
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TAP2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:1000
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 10 ug/ml
• Application Notes: IHC: NBP1-40335 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein G purified

Alternate Names for TAP2 Antibody

• ABC18
• ABCB3
• ABCB3ABC18
• antigen peptide transporter 2
• APT2
• ATP-binding cassette, sub-family B (MDR/TAP), member 3
• D6S217E
• MHC 2
• Peptide transporter involved in antigen processing 2
• Peptide transporter PSF2
• Peptide transporter TAP2
• PSF2
• PSF2PSF-2
• Really interesting new gene 11 protein
• RING11
• RING11ATP-binding cassette sub-family B member 3
• TAP2
• transporter 2, ABC (ATP binding cassette)
• transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
• Y1

Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TAP2
• Entrez:
  • 6891(Human)
• Uniprot:
  • Q03519()